Expert Medicinal Chemistry

Provid's expert medicinal chemistry supports organizations ranging from start-ups and virtual companies to large pharma as well as government labs and academic groups. 

Expert medicinal chemistry utilizes all the technical tools of synthetic and medicinal chemistry coupled with drug design, biostructural data and structure-activity results.  These tools are integrated with insight from experience on how drugs are discovered. 

In contrast to "custom synthesis" companies that produce compound libraries or simple analogs around a scaffold, expert medicinal chemistry focuses on outcome and objectives.  A small number of well-designed, information-rich compounds is much more valuable than large numbers of simple compounds that can be made in parallel, but have low information content.  Provid applies this hypothesis-driven model to transform the biological discoveries made by our customers into commercial opportunities. 

This has been a very productive model.  Since 2005, 8 client projects have advanced from discovery to development, and 3 of these have entered clinical trials.

Expert medicinal chemistry also exploits and integrates all the information available on a target and compound class (assays, biostructural data, related compounds and their potential 'on-" and "off-target" activities, as well as physical and ADME properties).